Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in Chinese Han subjects

Table 2 Main pharmacokinetic parameters of S-(-)- and R-(+)-propranolol glucuronide after an oral dose in Chinese Han healthy volunteers (n = 16).

Glucuronide	k (h-1)	t1/2 (h)	Tmax(h)	[Xu]0→24(mmoL)
S-PL	0.195±0.04b	3.56±0.7b	2.21±0.45b	5.65±0.98b
R-PL	0.283±0.06	2.45±0.5	1.75±0.33	2.95±0.62

Differences in mean values between S-(-)- and R-(+)-propranolol glucuronide were significant;

^bP<0.01 vs R-(+)-propranolol glucuronide.