Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications

Table 1 Clinicopathological characteristics of colorectal cancer patients associated with high and low serum IL-6, TNFα and CRP levels.

	Low IL-6 <8 pg/mL (n = 39)	High IL-6 ≥ 8 pg/mL (n = 35)	Low TNFa <5 pg/mL (n = 41)	High TNFa ≥5 pg/mL (n = 33)	Low CRP <7 mg/L (n = 36)	High CRP ≥7 mg/L (n = 38)
Age (yr)	661	701a	691	671	661	691
Gender ratio (M:F)	19:20	20:15	21:20	18:15	16:20	23:15
Tumor location
Cecum/ascending	7	9	7	8	6	10
Transverse	1	2	0	2	1	2
Descending/sigmoid	15	8	15	7	10	13
Rectum	10	14	10	14	13	11
Rectum/sigmoid	6	2	9	2	6	2
Differentiation
Good	1	2	2	2	2	1
Moderate	33	26	33	26	26	32
Poor	5	7	6	5	8	5
Preoperative CEA (ng/mL)	4.31	4.41	4.61	4.31	4.81	3.61
Preoperative CA19-9 (ng/mL)	121	91	121	101	101	121
Preoperative CA125 (ng/mL)	11.91	131	11.91	141	131	111
Preoperative TPA (ng/mL)	421	711	441	701	421	601
Maximum size of tumors (cm)	3.8±1.3a	4.8±1.9a2	3.8±1.62	4.7±1.6a2	3.7±1.22	4.8±1.92b
Growth characteristics
Ulcerative	12	19	25	13	15	23
Protruding	27	16	16	20	21	15
Lymph node metastasis
Positive	21	14	23	12	18	17
Negative	18	21	18	21	18	21
Dukes’ stage (%)
A	7	(54)	6	(46)	9	(69)
B	11	(46)	13	(54)	7	(29)
C	19	(63)	11	(37)	20	(67)
D	2	(29)	5	(71)	5	(71)

CRP, C-reactive protein; CEA, carcinoembryonic antigen; CA 19-9, carbohydrate antigen 19-9; CA 125, cancer antigen 125; TPA, tissue polypeptide antigen.

¹Values are median,

^aP<0.05 vs controls,

²Values are±SD,

^bP<0.01 vs low CRP group.