Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease

Table 1 Metabolic enzyme activities and special protein concentrations in normal LES and in LES operated due to gastroesophageal reflux, as well as in patients with and without complaints in the postoperative period.

Enzymes	LES				P	LES in GERD				P
	Normal		GERD			Visick I		Visick II–III
	Mean	SE	Mean	SE	Mean	SE	Mean	SE
CK	73027.3	32312.4	398220.7	210587.2	P<0.05	111904.3	29131.0	1098105.3	514604.5	P<0.001
LDH	23805.7	9561.9	127786.9	62210.7	P<0.05	44229.0	7850.8	332039.5	54804.5	P<0.001
HBDH	7960.3	3159.9	41400.3	20129.8	P<0.05	13906.0	2588.4	105553.7	47629	P<0.001
AST	2869.5	1453.0	13397.2	6825.7	P<0.05	3697.0	923	36030.9	14938.4	P<0.001
CK-MB	269.1	103.9	1580.3	1332.6	NS	597.5	185.3	3655.2	4374.7	NS
S-100	1252.5	844	10569.1	5038.1	P<0.05	3986.5	2123.0	26018.5	11485.7	P<0.001
MYO	750.3	538.3	11339.8	14029.3	NS	2395.8	1268.1	32581.8	52349.6	P<0.05
TNI	0.17	0.08	1.56	0.78	P<0.05	0.68	0.24	3.93	2.25	P<0.001

LES: lower esophageal sphincter; GERD: gastroesophageal reflux disease; Visick I: symptom-free; Visick II-III: mild symptoms can be treated with medication; SE: standard error; P: significance; NS: non-significant; CK: creatine kinase; LDH: lactate dehydrogenase; HBDH: α-hydroxybutyrate dehydrogenase; AST: aspartate aminotransaminase; CK-MB: creatine kinase MB (U/g soluble protein); S-100; MYO: myoglobin; TNI: troponin I (μg/g wet weight).