Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis

Figure 5 Immunostaining of HIF-1 alpha or VEGF in the colon tissues. Weak HIF-1 alpha or VEGF immunoreactive cells were scattered in epithelial cells and interstitial cells in normal colon tissue (A: HIF-1 alpha; B: VEGF). In contrast, strong HIF-1 alpha or VEGF immunoreactive cells were diffusely seen in the epithelial and intestinal cells, including inflammatory cells in the ischemic colitis lesions (C: HIF-1 alpha; D: VEGF). Scale bars represent 100 μm.