Hepatocyte growth factor gene therapy prevents radiation-induced liver damage

Figure 3 Histopathology of the liver 10 wk after 65 Gy of irradiation. A: rat liver (×200) receiving EGT-control-vector followed by 65 Gy of liver radiation 48 h later; B: rat liver (×200) receiving EGT-HGF followed by 65 Gy of liver radiation 48 h later. The blue stain indicated fibrosis formation. Fibrosis is more extensive with evidence of bile duct proliferation, sub-intimal thickening of arterioles with compromise of the vessel lumens. The morphology changes were less severe in HGF gene therapy group.