Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth

Figure 1 Proliferation assays showing cell numbers from mean counts of three experiments. Cells were treated as described in Materials and Methods with sirolimus, tacrolimus, or the combination of both. Sir = sirolimus; Tac = tacrolimus. Data are expressed as mean±SE. (A: SK-Hep 1: ^aP = 0.0105; ^bP = 0.0156; ^cP = 0.254; ^dP<0.0001; B: Hep 3B: ^eP<0.0001; ^fP = 0.0654; ^gP = 0.0002; ^hP<0.0001).