Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn’s disease: Phenotype-genotype correlations

Table 8 Genotype–phenotype associations with particular NOD2/CARD15 alleles in CD patients.

		None (n = 342)	SNP8 (n = 61)	SNP12 (n = 33)	SNP13 (n = 102)
Male/Female		174/168	28/33	14/19	51/51
Age (yr)		37.9±13.0	35.9±13.0	37.1±11.4	33.7±10.41
Age at presentation (yr)		29.8±12.1	26.6±10.9	28.8±10.0	26.0±8.41
Duration (yr)		8.1±7.0	9.3±7.6	11.4±6.42	7.7±6.1
Familiar IBD n (%)		38 (11.1)	9 (14.8)	7 (21.1)	11 (10.8)
Location	L1	84	16	7	322
	L2	103	12	5	16
	L3	152	33	20	53
	L4	3	0	1	1
Behavior	B1	151	22	8	34
	B2	71	15	13	31
	B3	120	14	12	37
Perianal disease n (%)		89 (26.0)	18 (29.5)	7 (21.1)	32 (31.4)
Frequent relapse n (%)		126 (36.9)	24 (39.3)	13 (39.4)	38 (37.3)
Extraintestinal manifestations n (%)		117 (34.2)	17 (27.8)	14 (42.4)	31 (30.4)
Arthritis n (%)		98 (28.7)	16 (26.2)	14 (42.2)	24 (23.5)
Occular n (%)		18 (5.2)	1 (1.6)	2 (6.1)	4 (3.9)
Erythema nodosum/
Pyoderma n (%)		30 (8.8)	5 (8.2)	4 (12.1)	7 (6.9)
PSC n (%)		15 (4.4)	1 (1.6)	0	2 (1.9)
Steroid use/		282 (82.4)/	51 (83.6)/	31 (93.9)/	88 (86.3)/
refractory n (%)		28 (9.3)	7 (13.7)	2 (16.1)	6 (6.8)
Azathioprine use/ refractory n (%)		208 (60.8)/	38 (62.3)/	32 (97)1/	69 (67.6)/
		10 (4.8)	4 (10.5)	2 (11.1)	3 (4.3)
Operationn (%)		128 (37.4)	27 (44.3)	23 (69.7)1	53 (52.0)2
Smoking habits	Never	191	44	21	65
	Active	115	12	9	33
	Previous	36	5	3	4

¹P<0.001 between carriers and non-carriers;

²P<0.03 between carriers and non-carriers.