Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn’s disease: Phenotype-genotype correlations

Table 4 NOD2/CARD15 SNP8, 12 and 13 in patients with Crohn’s disease (CD) and controls.

	R702W (SNP8)1		G908R(SNP12)		3020insC (SNP13)1
	CD n (%)	Controls n (%)	CD n (%)	Controls n (%)	CD n (%)	Controls n (%)
Wild type	466 (88.4)	188 (94.0)	494 (96.7)	193 (96.5)	425 (80.6)	190 (95.0)
All carriers	61 (11.6)	12 (6.0)	33 (6.3)	7 (3.5)	102 (19.4)	10 (5.0)
Heterozygous	45 (8.5)	12 (6.0)	33 (6.3)	7 (3.5)	89 (16.9)	10 (5.0)
Homozygous	16 (3.1)	0	0	0	13 (2.5)	0

¹P = 0.02 and P<0.0001 between patients and controls for genotype frequency by χ²-test, OR_{SNP8 allele} = 2.41 (1.30–4.44), OR_{SNP13 allele} = 4.78 (2.50–9.11).