Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy

Table 4 Factors affecting the local tumor recurrence within 1 year in 22 patients after RFA.

	Local recurrence (n = 3)	No local recurrence(n = 19)	P
Age (yr)	57.7±9.3	63.3±11.6	NS6
Sex (Male/Female)	2/1	14/5	NS
Child1 (A/B)	3/0	15/4	NS
Right lobe/Left lobe	2/1	14/5	NS
Subcapsular (+/-)	1/2	3/16	NS
HBV/HCV/others	1/2/0	8/8/3	NS
EV2 (+/-)	1/2	10/9	NS
Tumor size (cm)	3.2±0.7	2.2±0.7	0.03
Tumor >2 cm (+/-)	3/0	9/10	0.089
Histology
(Well/Poor)3	2/1	19/0	0.01
BCLCstage4 Ia/Ib/Ic	1/1/1	10/9	0.036
Roll-off (+/-)	3/0	18/1	NS
Ablative time (min)	27.0±12.3	20.4±14.0	NS
Sessions	1.3±0.6	1.2±0.4	NS
Follow-up (mo)	35.0±6.6	27.8±9.1	NS
Pre-RFA/Post-RFA
Albumin (g/dL)	3.6±0.3/4.0±1.0	3.9±0.5/4.2±0.5	NS/NS
T. Bili. (mg/dL)	1.2±0.6/1.1±0.2	1.0±0.5/1.0±0.5	NS/NS
GOT (U/L)	56.3±16.2/49.3±14.0	64.6±34.9/73.3±35.4	NS/NS
GPT (U/L)	50.0±24.4/56.3±20.1	74.4±41.4/82.8±34.9	NS/NS
Alk-P (U/L)	106.3±26.3/109.3±31.0	117.6±49.1/125.7±48.3	NS/NS
AFP5 (ng/mL)	967.7±1647.5/145.0±240.0	106.0±323.3/24.9±33.3	NS/NS
Decrease AFP > 50%	2/1	6/13	NS
Post-RFA(+/-)

¹Child: child-Pugh classification

²EV: esophageal varices

³Well/Poor: well differentiated/Poor differentiated

⁴BCLC stage: staging system from conclusions of the Barcelona-2000 EASL conference[16]

⁵AFP: alpha-fetoprotein

⁶NS: not significant.