Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: Implications on chemoprevention

Figure 1 Histological examination of apoptosis and proliferation. Apoptosis was examined by apoptotic nuclei counting (A) and verified by TUNEL (B). A representative apoptotic nucleus is illustrated by the black arrow. Representative H&E stained sections showing apoptotic bodies (red arrow) in (C) MNNG-treated tumors, (D) celecoxib-treated tumors and (E) indomethacin-treated tumors. (F-H) Ki-67 immunostaining was used in the assessment of proliferation. Representative proliferating cells in (F) MNNG treated tumors, (G) celecoxib-treated tumors and (H) indomethacin-treated tumors indicated by positive immunoreactivity against Ki-67.