Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis

Table 2 Hemodynamic parameters (mean±SD).

Parameter	Group	Baseline	6 h	12 h	24 h	36 h	48 h
MAP (mmHg)	1	126.5±7.76	95.5±10.20d	87.38±12.45d	81.83±5.08d	80.0±10.0d	NC
	2	126.3±7.19	95.6±7.44d	104.5±6.82ad	102.0±10.64ad	100.8±9.74ac	84.5±13.44
	3	123.3±4.43	117.8±9.07ac	116.3±7.80a	106.8±9.79ad	104.5±6.74ad	99.57±11.97
MPAP (mmHg)	1	24.5±1.51	25.0±1.07	26.8±1.16d	30.0±2.76d	27.3±3.06	NC
	2	24.3±2.25	26.1±2.59	26.4±2.33	28.4±3.58c	29.5±2.38	29.0±8.49
	3	24.4±1.85	25.9±1.25	22.1±1.81a	25.4±2.92a	27.3±3.58c	27.4±1.72
PCWP (mmHg)	1	10.1±1.96	9.1±2.85	10.8±1.98	14.2±3.19c	11.0±2.65	NC
	2	10.5±1.60	9.0±4.14	11.5±3.25	11.8±4.17	11.5±7.14	8.5±4.95
	3	10.3±0.71	8.8±1.98	9.6±1.60	10.3±2.87a	10.0±3.82	14.0±3.00
CVP (mmHg)	1	8.6±2.07	7.3±2.12	5.5±2.07c	9.2±3.92	9.0±1.73	NC
	2	8.0±2.14	8.6±4.41	7.6±3.85	8.6±2.50	11.5±6.24	7.0±5.66
	3	7.9±1.36	6.5±1.93	6.9±1.36	7.3±1.98	7.4±2.07	8.3±2.21
CI (L/min/m2)	1	4.5±0.55	6.2±0.64d	5.9±1.19c	3.1±0.41d	2.4±0.70	NC
	2	4.7±0.75	5.4±0.90c	5.9±0.86c	5.1±1.79a	4.6±2.43	3.7±0.12
	3	4.6±0.54	5.0±0.97a	4.2±0.73a	4.8±0.56a	5.3±1.10a	6.3±1.17
SVR (dyn.s.m-5)	1	2130.2±204.5	1176.8±253.9d	1465.0±788.3c	1915.8±397.8	3617.7±374.1d	NC
	2	2061.2±407.1	1329.6±354.8d	1349.9±218.6d	1573.0±633.1	1988.1±942.4a	1674.2±463.6
	3	2034.4±315.6	1820.8±380.3a	2172.3±371.7a	1664.6±268.1	1512.6±321.6a	1187.4±201.4

MAP: mean arterial pressure, MPAP: mean pulmonary artery pressure, PCWP: pulmonary capillary wedge pressure, CVP: central venous pressure, CI: cardiac index, SVR: systemic vascular resistance. Group 1: controls; group 2: low-volume continuous veno-venous hemofiltration (CVVH) (20 mL/kg body weight [BW]/h); group 3: high-volume CVVH (100 mL/kg BW); NC, not calculated (no survival).

^aP<0.05 and ^bP<0.01 vs the respective value in controls;

^cP<0.05 and

^dP<0.01 vs baseline values, respectively.