Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils

Table 1 Changes of gastric inflammation induced by indomethacin between H pylori infected, H pylori-eradicated and H pylori-uninfected gerbils (mean±SD).

H pylori-infected	H pylori-eradicated	H pylori-uninfected	P
Stomach weight ratio (×1000)	14.1±1.3	10.5±0.3	9.0±0.3	<0.05a
				<0.05c
Hyperplasia area (mm2)	82.4±9.2	13.9±3.5	0	<0.05a
				<0.05c
Erosion and ulcer area (mm2)	14.4±4.9	0.9±0.5	0	<0.05a
				<0.05c
Score of gastritis	7.0±0.0	3.6±0.5	0.8±0.4	<0.05a
				<0.05c
MPO activity (mmoL H2O2/min/g tissue)	104.7±9.2	8.9±2.3	7.8±2.5	<0.05a
				<0.05c
PGE2 synthesis (pg/mg wet weight/min)	299.2±81.5	102.8±26.2	9.6±1.3	<0.05a
				<0.05c

Stomach weight ratio: weight of stomach to weight of body ^aP<0.05, H pylori-infected vs H pylori-eradicated; ^cP<0.05, H pylori- infected vs H pylori uninfected.