Modulation of Kupffer cells on hepatic drug metabolism

doi:10.3748/wjg.v10.i9.1325

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May 1, 2004 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 1, 2004; 10(9): 1325-1328
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1325

Table 4 Influence of different dose of GdCl₃ on activities of S9-GSTpi, S9-GST and mGST

Group	S9-GSTpi	S9-GST (nmol/min·mg·pro)	mGST
Control	1.07 ± 0.28	8.3 ± 0.9	0.25 ± 0.03
GdCl₃10-1d	1.16 ± 0.0.19	9.8 ± 1.5^a	0.289 ± 0.026^a
GdCl₃20-1d	0.93 ± 0.17	10.2 ± 1.5^a	0.28 ± 0.06
GdCl₃40-1d	0.91 ± 0.12	7.9 ± 0.8	0.264 ± 0.012

The administration of GdCl₃ and the treatment of animals were the same as described in Table 1. S9-GST: glutathione s-trans-ferase in S9; S9-GSTpi: glutathione s-transferase pi in S9; mGST: glutathione s-transferase in microsome (n = 8, mean ± SD,

^aP < 0.05 compared with control group).

Citation: Ding H, Tong J, Wu SC, Yin DK, Yuan XF, Wu JY, Chen J, Shi GG. Modulation of Kupffer cells on hepatic drug metabolism. World J Gastroenterol 2004; 10(9): 1325-1328
URL: https://www.wjgnet.com/1007-9327/full/v10/i9/1325.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i9.1325