Modulation of Kupffer cells on hepatic drug metabolism

doi:10.3748/wjg.v10.i9.1325

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May 1, 2004 (publication date) through Jul 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 1, 2004; 10(9): 1325-1328
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1325

Table 3 Influence of ASP on P450 content, P450 isoform activities and activities of S9-GSTpi, S9-GST and mGST

Group	Control	ASP1	ASP2	ASP3
P-450 (nmol/mg·pro)	1.4 ± 0.4	2.1 ± 0.4^b	1.2 ± 0.4	0.60 ± 0.13^b
NADPH-C (nmol/min·mg·pro)	14.5 ± 2.8	19.7 ± 2.2^b	19.1 ± 4.3^a	7.6 ± 1.1^b
ANH (nmol/min·mg·pro)	0.038 ± 0.009	0.045 ± 0.009^b	0.018 ± 0.006^b	0.010 ± 0.003^b
AMD (nmol/min·mg·pro)	0.96 ± 0.07	1.29 ± 0.11^b	1.11 ± 0.19	0.61 ± 0.16^b
EMD (nmol/min·mg·pro)	0.89 ± 0.06	1.30 ± 0.21	1.14 ± 0.33	0.41 ± 0.09^b
S9-GSTpi (nmol/min·mg·pro)	1.07 ± 0.28	1.2 ± 0.3	1.15 ± 0.26	0.78 ± 0.19^a
S9-GST (nmol/min·mg·pro)	8.3 ± 0.9	0.5 ± 1.9^a	11.8 ± 1.5^a	7.9 ± 0.7^a
mGST (nmol/min·mg·pro)	0.25 ± 0.03	0.29 ± 0.03^a	0.35 ± 0.08^b	0.155 ± 0.016^b

ASP1, ASP2, ASP3: Mice were given 30, 60, and 120 mg/kg ASP, ig, qd × 7 d, respectively and sacrificed on day 7. The hepatic microsome was prepared to assay the content of P450, and activities of P450 isoforms, S9-GSTpi, S9-GST and mGST. (n = 8, mean ± SD,

^aP < 0.05,

^bP < 0.01 compared with control group).

Citation: Ding H, Tong J, Wu SC, Yin DK, Yuan XF, Wu JY, Chen J, Shi GG. Modulation of Kupffer cells on hepatic drug metabolism. World J Gastroenterol 2004; 10(9): 1325-1328
URL: https://www.wjgnet.com/1007-9327/full/v10/i9/1325.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i9.1325