1&alpha;, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital

doi:10.3748/wjg.v10.i9.1268

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May 1, 2004 (publication date) through Nov 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. May 1, 2004; 10(9): 1268-1275
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1268

Table 7 Changes in total hepatic reduced glutathione (GSH) (mg/100 g tissue) level in different groups of rats treated with 1α, 25(OH)₂D₃ during DEN induced rat hepatocarcinogenesis promoted by phenobarbital (mean ± SE, n = 5)

Groups	Nodules	Surrounding	Control
A	367.6 ± 25.5^b	310.0 ± 24.9^c	226.0 ± 22.5
C	268.0 ± 21.5^a	254.0 ± 20.1	248.0 ± 21.7
E	303.2 ± 22.5	284.0 ± 21.6	256.0 ± 22.5

Statistical level of significance by using Dunnett’s t-test.

^bP < 0.01,

^cP < 0.05 compared with control.

^aP < 0.05 compared with group A.

Citation: Banakar MC, Paramasivan SK, Chattopadhyay MB, Datta S, Chakraborty P, Chatterjee M, Kannan K, Thygarajan E. 1α, 25-dihydroxyvitamin D₃ prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital. World J Gastroenterol 2004; 10(9): 1268-1275
URL: https://www.wjgnet.com/1007-9327/full/v10/i9/1268.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i9.1268