1&alpha;, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital

doi:10.3748/wjg.v10.i9.1268

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May 1, 2004 (publication date) through Nov 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. May 1, 2004; 10(9): 1268-1275
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1268

Table 5 Changes in activities of superoxide dismutase (units/mg protein) in different groups of rats treated with 1α, 25(OH)₂D₃ during DEN induced rat hepatocarcinogenesis promoted by phenobarbital (mean ± SE, n = 5)

Groups	Nodules	Surrounding	Control
A	4.38 ± 0.56^b	5.28 ± 0.57^a	8.64 ± 0.87
C	6.84 ± 0.81^c	7.60 ± 0.73	8.84 ± 0.80
E	4.88 ± 0.66	5.64 ± 0.53	8.52 ± 0.77

Statistical level of significance by using Dunnett’s t-test.

^bP < 0.01,

^aP < 0.05, compared with control.

^cP < 0.05 compared with group A.

Citation: Banakar MC, Paramasivan SK, Chattopadhyay MB, Datta S, Chakraborty P, Chatterjee M, Kannan K, Thygarajan E. 1α, 25-dihydroxyvitamin D₃ prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital. World J Gastroenterol 2004; 10(9): 1268-1275
URL: https://www.wjgnet.com/1007-9327/full/v10/i9/1268.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i9.1268