Effects of autoantibodies against β1-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca2+ currents

Figure 3 Effects of anti-β₁-receptor autoantibodies on peak current amplitude of I_Ca-L in the absence and presence of 1 μmol/L metoprolol. A and B (left): time-course changes of peak cur-rent amplitude of I_Ca-L before and after superfusion with anti-β₁-receptor autoantibodies diluted at 1:80 (A) or in the pres-ence of 1 μmol/L metoprolol (B). A and B (right): traces of I_Ca-L before and after superfusion with anti-β₁-receptor autoanti-bodies diluted at 1:80 (A) or before and after superfusion with anti-β₁-receptor autoantibodies diluted an 1:80 in the pres-ence of 1 μmol/L metoprolol (B). ^arepresents the maximal peak current amplitude of I _Ca-L before superfusion with anti-β₁-receptor autoantibodies diluted at 1:80, ^brepresents the maximal peak current amplitude of I_Ca-L after superfusion with anti-β₁-receptor autoantibodies diluted an 1:80. ^crepresents the maximal peak current amplitude of I_Ca-L after superfusion with anti-β₁-receptor autoantibodies diluted at 1:80 in the pres-ence of 1 μmol/L metoprolol. C: concentration dependence of anti-β₁-receptor autoantibodies. The numbers in brackets in-dicate the number of cells studied at each concentration.