Significant correlation between expression level of HSP gp96 and progression of hepatitis B virus induced diseases

Figure 1 Sections of immunoperoxidase staining for gp96 in chronic hepatitis liver, liver cirrhosis and HCC. Several representa-tive liver tissues with A: gp96 negative in chronic hepatitis, B: gp96 weakly positive in chronic hepatitis, C: gp96 strongly positive in chronic hepatitis, D: gp96 strongly detected in liver cirrhosis, E: gp96 strongly positive in HCC, F: gp96 positive in the nuclear and cytoplasmic staining, G: Cytoplasmic gp96 staining significantly higher in HCC cells than in adjacent non-tumorous liver cells, and H: gp96 expression in HCC accompanied by lymphocyte infiltration (indicated by arrow).