Therapeutic polypeptides based on HBcAg18-27 CTL epitope can induce antigen-specific CD8+ CTL-mediated cytotoxicity in HLA-A2 transgenic mice

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Apr 15, 2004 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 2004; 10(8): 1222-1226
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1222

Table 1 TH1 polarization assay with an IFN-γ ELISPOT method. (mean ± SD, n = 18)

	Peptide1	Peptide2	Peptide3	MART-1_27-35	Negative controls
ISC/10⁶ lymphocytes	1 150 ± 236.7^d	1 367 ± 231^d	8 050 ± 1 233.8^d^b	1 135 ± 312	250 ± 138

^dP < 0.01 vs negative control;

^bP < 0.01 vs peptide1 and 2 groups.

Citation: Shi TD, Wu YZ, Jia ZC, Zhou W, Zou LY. Therapeutic polypeptides based on HBcAg_18-27 CTL epitope can induce antigen-specific CD₈⁺ CTL-mediated cytotoxicity in HLA-A2 transgenic mice. World J Gastroenterol 2004; 10(8): 1222-1226
URL: https://www.wjgnet.com/1007-9327/full/v10/i8/1222.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i8.1222