Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock protein 70 in signal transduction during hepatocyte ischemic preconditioning

Figure 2 Changes of cellular ultrastructure after treatment with IR, IP, IR + PMA, IP + CHE, and IP + PD98059. A: Effect of hy-poxia reoxygenation on hepatocytes, B: Cytoprotective effects of hypoxic preconditioning, C: Preconditioning effects mim-icked by stimulation of PKC with PMA, D: Preconditioning protection abolished by inhibition of PKC with chelerythrine, E: Cytoprotection of preconditioning reverted by PD98059.