Effect of cold-ischemia time on nuclear factor-κB activation and inflammatory response in graft after orthotopic liver transplantation in rats

Figure 3 Changes in intrahepatic inflammatory mediator responses after reperfusion. A: TNF-α levels, B: CINC levels, C: ICAM-1 levels. TNF-α levels significantly increased in the 24 h and 18 h groups 0.5 h after reperfusion, compared with the 6 h group (P < 0.05, respectively). CINC levels significantly in-creased in the 24 h and 18 h groups 2 h after reperfusion, com-pared with the 6 h group (P < 0.05, respectively). ICAM-1 levels significantly increased in the 24 h and 18 h cold-preserved groups 1 h after reperfusion, compared with the 6 h group (P < 0.05, respectively). Results are mean ± SD for each time point in each group (n = 6). 6 h group—closed triangle, 24 h group— closed square, and 18 h group—closed circle.