Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

doi:10.3748/wjg.v10.i7.1032

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Apr 1, 2004 (publication date) through Mar 13, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 1, 2004; 10(7): 1032-1036
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.1032

Table 4 Effects of BPC 157 on rebuilding of glandular epithe-lium and formation of granulation tissue in acetate induced chronic gastric ulcer (n = 10)

Administration	Agent	Dosage (ng/kg)	Diameter of remnant ulcer (μm)	Thickness of granulation tissue (μm)
im	Saline control		3 928 ± 636	718 ± 165
	Excipient control		3 981 ± 594	652 ± 169
	Famotidine	40 000	3 175 ± 577^b	768 ± 268
	BPC 157	200	3 266 ± 671^a	992 ± 295^b
	BPC 157	400	2 658 ± 744^b	1 018 ± 202^b
	BPC 157	800	2 426 ± 511^b	1 012 ± 306^b
ig	Saline control		4 098 ± 795	673 ± 112
	Famotidine	40 000	1 772 ± 458^b	805 ± 100^a
	BPC 157	200	3 260 ± 728^a	797 ± 110^a
	BPC 157	400	2 972 ± 564^b	837 ± 114^b
	BPC 157	800	2 904 ± 577^b	862 ± 171^b

^aP < 0.05,

^bP < 0.01 vs excipient control (im) or saline control (ig).

Citation: Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, Bao CJ, Yan Z, Zhang YQ. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol 2004; 10(7): 1032-1036
URL: https://www.wjgnet.com/1007-9327/full/v10/i7/1032.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i7.1032