Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation

Figure 4 Impact of GSH treatment on the hepatic microcirculation after liver transplantation. Data from in vivo microscopy were obtained 30 min after starting reperfusion comparing untreated controls (n = 8) with GSH- treated allografts (50 µmol/(h·kg) and 100 µmol/(h·kg); each n = 5) as well as to a sham group (n = 5). (A) Acinar perfusion failure is indicated as the percentage of non-perfused sinusoids (no reflow). (B) Leukocyte-adhesion (sticking) to sinusoids and (C) to postsinusoidal venules. (D) Temporary attachment of leukocytes (rolling) to the endothelium of postsinusoidal venules (PSV). Results are mean ± SE. ^aP < 0.05, ^dP < 0.01 and ^bP < 0.001 vs sham group. ^fP < 0.001 vs control group.