Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation

Figure 1 ALT (A) and AST (B) plasma levels after liver transplantation. Livers preserved for 24 h in UW solution at +4 °C before transplantation. Compared to untreated livers (n = 8) administration of 100 µmol GSH/(h·kg) (n = 5), but not of 50 µmol GSH/(h·kg) (n = 5), resulted in a significant decrease of plasma ALT and AST levels at 2 h of reperfusion. Results are mean ± SE. ^bP < 0.001 vs sham- operated animals (n = 5); ^aP < 0.05 vs untreated livers.