Effect of mitogen-activated protein kinase signal transduction pathway on multidrug resistance induced by vincristine in gastric cancer cell line MGC803

Figure 2 Cell cycle analysis of MGC803. A: Untreated MGC803 cells at 72 h (G₀G₁: 48.20%; G₂M: 28.18%, S: 14.16%, apoptosis: 8.46%), B: MGC803 cells treated with VCR (20 ng/mL) after 72 h (G₀G₁: 37.62%; G₂M: 20.05%, S: 24.92%, apoptosis: 18.41%), C: MGC803 cells treated with VCR (20 ng/mL) + PD098059 (10 nmol/mL) after 72 h (G₀G₁: 32.53%; G₂M: 13.91%, S: 18.95%, apoptosis: 35.61%), D: MGC803 cells treated with PD098059 (10 nmol/mL) only after 72 h (G₀G₁: 49.27%; G₂M: 27.56%, S: 16.91%, apoptosis: 6.26%).