Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus

doi:10.3748/wjg.v10.i6.847

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Mar 15, 2004 (publication date) through Feb 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Mar 15, 2004; 10(6): 847-851
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.847

Table 3 Predicted CTL epitopes by MHC binding peptide motifs while incorporating persistent substitutions

Patient	HLA sutype	MHC binding peptide motif[38,39]	Genome position	Predicted epitope	Time point measured
C	A11	X[MLIVSATGNCDF]XXXXXX[KRHY]	1349	ATPPGSITVPH*	0 mo
				ATPPGSVTVPH*	32^th, 60^th mo
			1378	KAIPIEAIR	0 mo
				KAIPIEAIK	32^th, 60^th mo
Z	A11	X[MLIVSATGNCDF]XXXXXX[KRHY]	1381	PIEAIKGGR	0 mo
				PIEAIRGGR	32^th, 60^th mo
			1347	ATATPPGSV	0 mo
				ATATPPGSI	32^th, 60^th mo
	A 2	X[LMIVAT]XXXXXX[LVIAMT]	1348	TATPPGSVT	0 mo
				TATPPGSIT	32^th, 60^th mo
			1349	ATPPGSVTV	0 mo
				ATPPGSITV	32^th, 60^th mo

*These two peptides fitted the MHC binding motif because proline and glycine residues allowed flexibility which made the peptides accommodate to the motif by kinking in the peptide backbone[40].

Citation: Guo HZ, Yin Y, Wang WL, Zhang CS, Wang T, Wang Z, Zhang J, Cheng H, Wang HT. Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus. World J Gastroenterol 2004; 10(6): 847-851
URL: https://www.wjgnet.com/1007-9327/full/v10/i6/847.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i6.847