Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma

Figure 2 A: Schematic diagram of LUC reporter plasmids. Pro-moter fragments of decreasing size from the 5’ end (1375 bp, 776 bp, 100 bp and Myc double deletion mutant hTERT-pro-moter reporter plasmids of 181 bp) upstream of the initiating ATG were inserted into luciferase (LUC) reporter vector pGL3-Basic in sense orientation. +1, the transcription start site. Bind-ing sites for c-Myc/Max and Sp1 are shown. B: Transcription activation of hTERT promoter. Data represent normalized rela-tive luciferase fold activity compared with the promoterless pGL3 basic plasmid.