Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma

Table 1 Clinicopathologic findings in patients with early gas-tric carcinoma with and without lymph node metastasis

	Node-negative	Node-positive	P value
	n = 673, (%)	n = 75, (%)
Age (mean, yr)	55.7 ± 10.7	57.9 ± 10.7	NS
Gender			< 0.05
Male	453 (67.3)	41 (54.7)
Female	220 (32.7)	34 (45.3)
Age (yr)			NS
≤ 40	71 (10.5)	5 (6.7)
> 40	602 (89.5)	70 (93.3)
Tumor size (mean, cm)	2.2 ± 1.45	3.1 ± 1.89	< 0.01
< 2	434 (64.5)	10 (13.3)	< 0.01
2-3	141 (21.0)	24 (32.0)
> 3	98 (14.5)	41 (54.7)
Tumor location			NS
Upper	28 (4.2)	2 (2.7)
Middle	200 (29.7)	18 (24.0)
Lower	445 (66.1)	55 (73.3)
Macroscopic appearance			NS
Protruded	208 (30.9)	21 (28.0)
Depressed	417 (62.0)	50 (66.7)
Mixed	48 (7.1)	4 (5.3)
Stage			< 0.01
Ia	672 (99.9)
Ib		65 (86.7)
II		6 (8.0)
IV	1 (0.1)	4 (5.3)
Histologic type			< 0.01
Differentiated	348 (51.7)	24 (32.0)
Undifferentiated	325 (48.3)	51 (68.0)
Depth of invasion			< 0.01
Mucosa	363 (53.9)	14 (18.7)
Submucosa	310 (46.1)	61 (81.3)
Operative type			NS
Total gastrectomy	62 (9.2)	8 (10.7)
Proximal gastrectomy	4 (0.6)
Distal gastrectomy	583 (86.8)	65 (86.7)
Others	24 (3.4)	2 (2.7)
Lymph node dissection			< 0.01
D1	144 (21.4)	8 (10.7)
D2	484 (71.9)	50 (66.7)
≥ D3	45 (6.7)	17 (22.7)
Curability			NS
Curative	671 (99.7)	73 (97.3)
Non-curative	2 (0.3)	2 (2.7)

NS, not significant.