Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension

Table 3 Effects of anti-rat TNFα and L- NMMA on homodynamic variables

Groups	SV	CO	PP	SMAflow	IAflow	VRSMA	VRIA
	(mL/s)	(L/min)	(kPa)	(mL/min)	(mL/min)	(kPa/.L·min)	(kPa/.L·min)
Control	0.162 ± 0.04	0.05 ± 0.017	0.91 ± 0.16	8.42 ± 1.16	10 ± 0.89	15.57 ± 2.74	13.58 ± 2.19
cPHT	0.59 ± 0.06ac	0.159 ± 0.031ac	2.26 ± 0.34ac	27 ± 3.19ac	27.33 ± 1.21ac	4.07 ± 0.43ac	4.44 ± 0.51ac
CPHT+anti-rat TNFα	0.39 ± 0.08a	0.138 ± 0.029a	1.53 ± 0.13a	20.75 ± 1.92a	24.15 ± 1.67a	5.56 ± 0.59a	5.21 ± 0.51a
cPHT+L-NMMA	0.32 ± 0.02a	0.076 ± 0.005e	1.12 ± 0.08e	12.75 ± 0.82ae	16.08 ± 0.74ae	10.13 ± 0.26ae	8.84 ± 0.66ae
PVL72 h	0.42 ± 0.03ag	0.143 ± 0.029ag	2.38 ± 0.05ag	23.27 ± 1..52ag	25.43 ± 1.44ag	4.44 ± 0.28ag	4.54 ± 0.32ag
PVL72 h+anti-rat TNFα	0.33 ± 0.02a	0.127 ± 0.008a	1.68 ± 0.12a	19.3 ± 1.1a	20.7 ± 2a	5.9 ± 0.1a	6.0 ± 0.5a
PVL72 h+L-NMMA	0.24 ± 0.04i	0.072 ± 0.013i	0.85 ± 0.15i	9.82 ± 0.96i	10.77 ± 1.11i	12.58 ± 0.93i	12.42 ± 0.99i

^aP < 0.05 vs control,

^cP < 0.05 cPHT group compared with cPHT+anti-rat TNFα and cPHT+L-NMMA groups respectively,

^eP < 0.05 cPHT+anti-rat TNFα compared with cPHT+L-NMMA groups,

^gP < 0.05 PVL 72 h group compared with PVL 72 h+anti-rat TNFα and PVL 72 h+L-NMMA groups respectively,

ⁱP < 0.05 PVL 72 h+anti-rat TNFα compared with PVL 72 h+L-NMMA.