Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension

Table 1 Serum levels of TNFα, ET-1 and NO and hepatic NOS activities in PVL and cPHT rats

Groups	TNFα	ET-1	NO	NOS
	(pg/min)	(pg/min)	(µmol/L)	(u/mg·prot)
Control	48.67 ± 32.79	8.72 ± 0.79	113 ± 15	0.9 ± 0.03
aPHT
PVL0.5 h	50 ± 15	13.4 ± 2.6	128.64 ± 18.29	0.86 ± 0.14
PVL24 h	328 ± 100ac	12.8 ± 5.7	169.40 ± 21.07ac	1.45 ± 0.17ac
PVL48 h	428 ± 69a	13.5 ± 2.6	223.71 ± 35.44a	1.7 ± 0.12a
PVL72 h	416 ± 48a	13.1 ± 3.2	215.49 ± 12.75a	1.67 ± 0.16a
PVL120 h	425 ± 49a	13.4 ± 3.5	225.36 ± 18.66a	1.7 ± 0.12a
cPHT	477.67 ± 83.81ae	14.33 ± 4.42	278.41 ± 20.11ae	1.81 ± 0.06a

^aP < 0.05 vs control,

^cP < 0.05 PVL 24 h group compared with PVL 48 h, 72 h, 120 h and cPHT groups respectively,

^eP < 0.05 cPHT group compared with PVL 48 h, 72 h, 120 h groups respectively.