Copyright
©The Author(s) 2004.
World J Gastroenterol. Feb 15, 2004; 10(4): 497-504
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.497
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.497
Table 2 Differential expressions of important genes
| Coordinate | Genbank | Gene Name | 1 | 2 | 3 | 4 | 5 | 6 |
| BC/BA | NCL/BC | HCC/NCL | HCC/BC | HCC/BA | HCC/C | |||
| Oncogenes & tumor suppressors (1/57, 1.8%) | ||||||||
| A1i | X12795 | v-erbA related protein 3 (EAR3) | ↑(3.56) | ↑(7.45) | ↑(4.80) | |||
| Cell Cycle Regulators (1/41, 2.4%) | ||||||||
| A6i | L26584 | cell division cycle 25 homolog (CDC25) | ↑(3.43) | ↑(5.92) | ||||
| Ion channels & transport proteins (0/3) | ||||||||
| Modulators, effectors & intracellular transducers (5/88, 5.7%) | ||||||||
| B1f | M62424 | thrombin receptor (TR) | ↓(0.15) | ↑(5.64) | ↑(10.75) | ↑(6.52) | ||
| B1l* | X74764 | neurotrophic tyrosine kinase | ↑(5.50) | ↑(2.63) | ↑(14.05) | ↑(25.36) | ||
| receptor-related 3 | ||||||||
| B2j | D21878 | bone marrow stromal antigen 1 (BST-1) | ↓(0.15) | ↑(11.14) | ↑(3.40) | |||
| B4l | U07707 | epidermal growth factor receptor | ↓(0.40) | ↑(2.87) | ↑(2.18) | |||
| substrate 15 (EPS15) | ||||||||
| B5m* | M65066 | cAMP-dependent protein kinase type I | ↓(0.02) | ↑(4.03) | ↑(11.35) | ↑(51.59) | ||
| beta regulatory subunit (PRKAR1B) | ||||||||
| Stress response proteins (1/7, 14.3%) | ||||||||
| B7m | M11717 | heat shock 70-kDa protein 1 (HSP70.1) | ↓(3.54) | ↑(0.26) | ↑(0.26) | ↑(0.17) | ||
| Apoptosis-associated proteins (15/64, 23.4%) | ||||||||
| C1g | M14694 | p53 cellular tumor antigen | ↓(0.35) | ↓(0.10) | ||||
| C1n | L07414 | TNF-related activation protein (TRAP) | ↓(0.42) | ↓(0.24) | ||||
| C3c | M25627 | glutathione S-transferase A1 (GSTA1) | ↓(0.29) | ↓(0.23) | ||||
| C3j | M13228 | N-myc proto-oncogene | ↑(181.47) | ↓(0.30) | ↑(148.98) | ↓(0.18) | ||
| C3k | U25994 | receptor (TNFRSF)-interacting | ↑(4.61) | ↓(0.25) | ↓(0.06) | |||
| serine-threonine kinase 1 (RIPK1) | ||||||||
| C3n | L11015 | tumor necrosis factor C (TNFC) | ↓(0.24) | ↓(0.08) | ||||
| C4c* | U15172 | NIP1 (NIP1) | ↓(0.08) | ↓(0.16) | ↓(0.20) | |||
| C4d* | U15174 | BCL2/adenovirus E1B 19-kDa- | ↓(0.31) | ↓(0.34) | ↓(0.21) | |||
| interacting protein 3 (BNIP3) | ||||||||
| C4f | U23765 | BCL2 homologous | ↓(0.28) | ↓(0.12) | ||||
| antagonist/killer 1 (BAK1) | ||||||||
| C4h | U29680 | BCL2-related protein A1 (BCL2A1) | ↑(8.19) | ↓(0.16) | ↓(0.09) | |||
| C4k | U45880 | inhibitor of apoptosis protein 3 (IAP3) | ↑(4.53) | ↓(0.42) | ↓(0.23) | |||
| C4m* | U57059 | TNF-related apoptosis inducing | ↓(0.26) | ↓(0.20) | ↓(0.40) | |||
| ligand (TRAIL) | ||||||||
| C5c | Y09392 | WSL protein+TRAMP+Apo-3+ | ↓(0.39) | ↓(0.20) | ||||
| death domain receptor 3 (DDR3) | ||||||||
| C5f | U39613 | cysteine protease ICE-LAP3 | ↓(0.13) | ↓(0.03) | ||||
| C5h | U71364 | cytoplasmic antiproteinase 3 (CAP3) | ↑(44.85) | ↓(0.28) | ↓(0.13) | |||
| DNA synthesis, repair & recombinant proteins (15/34, 44.1%) | ||||||||
| C5k* | L07540 | replication factor C 36-kDa | ↓(0.24) | ↑(6.73) | ↓(0.26) | ↓(0.26) | ↓(0.17) | |
| subunit (RFC36) | ||||||||
| C6a | M30938 | nuclear factor IV | ↓(0.25) | ↓(0.07) | ||||
| C6b | M31899 | xeroderma pigmentosum group B | ↓(0.06) | ↓(0.04) | ||||
| complementing protein (XPB-ERCC3) | ||||||||
| C6c | M32865 | 70-kDa thyroid autoantigen (TLAA) | ↓(0.44) | ↓(0.20) | ||||
| C6e | M63488 | replication protein A 70-kDa | ↓(0.25) | ↓(0.07) | ||||
| subunit (RPA70) | ||||||||
| C6l | J04088 | DNA topoisomerase II alpha (TOP2A) | ↑(4.00) | ↓(0.33) | ↓(0.30) | |||
| C7a | M13194 | excision repair cross-complementing | ↓(0.26) | ↓(0.09) | ||||
| rodent repair deficiency | ||||||||
| complementation group 1 (ERCC1) | ||||||||
| C7b | M13267 | cytosolic superoxide dismutase 1 (SOD1) | ↓(0.39) | ↓(0.24) | ||||
| C7c | U07418 | colon cancer nonpolyposis type | ↓(0.30) | ↓(0.10) | ||||
| 2 protein (COCA2) | ||||||||
| C7d* | D21090 | UV excision repair protein RAD23 | ↓(0.26) | ↓(0.44) | ↓(0.08) | |||
| homolog B (hHR23B; XPC repair- | ||||||||
| complementing complex 58-kDa protein) | ||||||||
| C7g | S40706 | growth arrest & DNA damage-inducible | ↓(0.29) | ↓(0.15) | ||||
| protein 153 (GADD153) | ||||||||
| C7i | U12134 | DNA damage repair & recombination | ↑(6.02) | ↓(0.27) | ↓(0.12) | |||
| protein 52 homolog (RAD52) | ||||||||
| C7k | U63139 | DNA damage repair & recombination | ↓(0.18) | ↓(0.08) | ||||
| protein 50 homolog (RAD50) | ||||||||
| C7m | X84740 | DNA ligase III (LIG3) | ↑(4.23) | ↓(0.21) | ↓(0.08) | |||
| C7n | X90392 | muscle-specific DNase I-like (DNL1L) | ↓(5.36) | ↓(0.22) | ↓(0.12) | |||
| Transcription factors & DNA-bingding proteins (8/98, 8.2%) | ||||||||
| D3a | D26155 | SWI/SNF-related matrix-associated | ↓(0.19) | ↑(3.85) | ↑(4.58) | ↑(2.55) | ||
| actin-dependent regulator of chromatin | ||||||||
| subfamily A member 2 (SMARCA2) | ||||||||
| D4b* | M36542 | octamer-binding transcription | ↑(2.64) | ↑(8.32) | ↑(7.33) | ↑(3.30) | ||
| factor 2 (OCT2) | ||||||||
| D4e | M62810 | mitochondrial transcription | ↑(8.04) | ↑(25.07) | ||||
| factor 1 (MTTF1) | ||||||||
| D4j | M76541 | transcriptional repressor protein | ↓(0.32) | ↑(2.73) | ↑(3.74) | ↑(3.10) | ||
| yin & yang 1 (YY1) | ||||||||
| D5a* | M83234 | nuclease-sensitive element | ↑(2.59) | ↑(3.24) | ↑(2.75) | ↑(5.21) | ||
| DNA-binding protein (NSEP) | ||||||||
| D5f | M96824 | nucleobindin 1 (NUCB1) | ↓(0.24) | ↑(2.64) | ↑(3.00) | ↑(2.37) | ||
| D6h* | U10324 | nuclear factor NF90 | ↑(3.69) | (2.34) | ↑(2.90) | |||
| D6l | U14575 | activator of RNA decay (ARD-1) | ↑(72.46) | ↑(2.53) | ↑(93.75) | |||
| Growth factor & chemokine receptors (1/25, 4.0%) | ||||||||
| E1h | L06623 | endothelin receptor type B (ETB) | ↓(0.37) | ↑(4.46) | ↑(2.07) | ↑(2.78) | ||
| Interleukin & interferon receptors (0/18) | ||||||||
| Hormone receptors (0/4) | ||||||||
| Neurotransmitter receptors (0/11) | ||||||||
| Cell surface antigens & adhesion proteins (3/40, 7.5%) | ||||||||
| E5l | M23197 | myeloid cell surface CD33 antigen | ↑(6.68) | ↑(5.75) | ↑(3.26) | |||
| E6f* | M74777 | dipeptidyl peptidase IV (DPP IV); | ↓(0.32) | ↓(0.36) | ↓(0.28) | |||
| T-cell activation CD26 | ||||||||
| E7b | M35198 | integrin beta 6 (ITGB6) | ↑(5.44) | ↓(0.44) | ↓(0.36) | |||
| Growth factors, cytokines & chemokines (20/64, 31.3%) | ||||||||
| F1f | X03438 | granulocyte colony-stimulating | ↑(8.95) | ↑(3.32) | ↓(0.05) | ↓(0.18) | ↓(0.06) | |
| factor (GCSF) | ||||||||
| F1j* | M16552 | thrombomodulin (THBD) | ↓(0.10) | ↓(0.24) | ↓(0.23) | |||
| F2a | D16431 | hepatoma-derived growth factor (HDGF) | ↓(0.39) | ↓(0.28) | ||||
| F2c | J04130 | T-cell activation protein 2 (AT2) | ↓(0.17) | ↓(0.20) | ||||
| F2e | K03515 | neuroleukin (NLK) | ↑(9.09) | ↓(0.40) | ↓(0.26) | |||
| F2f | L12260 | neuregulin 1 (NRG1) | ↑(21.23) | ↓(0.10) | ↑(3.76) | ↓(0.13) | ||
| F2g | L12261 | heregulin-beta3 | ↑(6.10) | ↓(0.10) | ↓(0.14) | |||
| F2h | L36052 | thrombopoietin (THPO) | ↑(7.26) | ↓(0.04) | ↓(0.24) | ↓(0.06) | ||
| F2m | M22491 | bone morphogenetic protein 3 (BMP3) | ↓(0.05) | ↓(0.08) | ||||
| F3a | M24545 | small inducible cytokine subfamily | ↓(0.36) | ↓(0.34) | ||||
| A member 2 (SCYA2) | ||||||||
| F3d | M30704 | amphiregulin (AR) | ↑(3.69) | ↓(0.17) | ↓(0.41) | ↓(0.12) | ||
| F3i | M57502 | small inducible cytokine subfamily | ↓(0.22) | ↓(0.27) | ||||
| A member 1 (SCYA1) | ||||||||
| F3l | M60718 | hepatocyte growth factor (HGF) | ↓(0.20) | ↓(0.30) | ||||
| F4c | M74178 | hepatocyte growth factor-like protein | ↓(0.31) | ↑(5.11) | ↑(4.62) | ↓(2.28) | ||
| F4e | M92934 | connective tissue growth factor (CTGF) | ↑(3.86) | ↑(6.00) | ↓(0.30) | ↑(5.44) | ↓(0.24) | |
| F4h | U43142 | vascular endothelial growth | ↑(8.75) | ↑(3.82) | ↓(0.14) | ↑(4.81) | ↓(0.15) | |
| factor C (VEGFC) | ||||||||
| F4i | X02530 | small inducible cytokine subfamily | ↑(5.60) | ↑(4.14) | ↓(0.14) | ↑(3.17) | ↓(0.15) | |
| B member 10 (SCYB10) | ||||||||
| F4k | X06234 | calgranulin A (CALA) | ↓(0.21) | ↓(0.21) | ||||
| F4n | X51943 | AFGF + HBGF-1 + ECGF-beta | ↓(0.10) | ↓(0.19) | ||||
| F5e | X79929 | OX40 ligand (OX40L) | ↑(5.42) | ↓(0.11) | ↓(0.31) | ↓(0.09) | ||
| Interleukins & interferons (12/20, 60.0%) | ||||||||
| F5j | J04156 | interleukin 7 (IL7) | ↑(3.62) | ↓(0.25) | ↓(0.27) | |||
| F5k | A14844 | interleukin 2 (IL2) | ↑(11.82) | ↓(0.14) | ↓(0.16) | ↓(0.13) | ||
| F5l | X02851 | interleukin 1 alpha (IL1-alpha) | ↓(0.19) | ↓(0.24) | ||||
| F5n | M14743 | interleukin 3 (IL3) | ↑(11.18) | ↓(0.08) | ↓(0.06) | |||
| F6a | M13982 | interleukin 4 (IL4) | ↑(2.87) | ↓(0.26) | ↓(0.22) | |||
| F6b* | X04602 | interleukin 6 (IL6) | ↑(3.37) | ↑(2.73) | ↑(9.47) | ↑(12.41) | ||
| F6d | M28622 | interferon beta 1 (IFN-beta 1) | ↓(0.17) | ↓(0.16) | ||||
| F6g | L06801 | interleukin 13 (IL13) | ↓(0.20) | ↑(5.04) | ↑(5.90) | ↓(2.36) | ||
| F6i | M57765 | interleukin 11 (IL11) | ↑(4.15) | ↓(0.11) | ↓(0.40) | ↓(0.10) | ||
| F6j | M65290 | interleukin 12 beta subunit (IL12-beta) | ↑(2.71) | ↓(0.19) | ↓(0.18) | |||
| F6k | M65291 | interleukin 12 alpha subunit | ↑(3.78) | ↓(0.17) | ↓(0.14) | |||
| (IL12-alpha) | ||||||||
| F6l | U14407 | interleukin 15 (IL15) | ↑(3.36) | ↓(0.24) | ↓(0.30) | |||
| Hormones (7/14, 50.0%) | ||||||||
| F7d | A06925 | prorelaxin H2 (RLN2) | ↓(0.23) | ↓(0.16) | ||||
| F7f | J04040 | glucagon (GCG) | ↑(5.75) | ↓(0.17) | ↓(0.12) | |||
| F7i | M31159 | insulin-like growth factor-binding | ↓(0.35) | ↓(0.35) | ||||
| protein 3 ( IGFBP3) | ||||||||
| F7j | M68867 | cellular retinoic acid-binding | ↑(2.84) | ↓(0.27) | ↓(0.23) | |||
| protein II (CRABP2) | ||||||||
| F7l | X58022 | corticotropin-releasing | ↑(5.00) | ↑(2.97) | ↓(0.12) | ↓(0.36) | ↓(0.16) | |
| factor-binding protein | ||||||||
| F7m | U08098 | estrogen sulfotransferase (STE; EST) | ↑(5.62) | ↑(3.44) | ↑(12.98) | |||
| F7n | X54469 | preprotachykinin beta (beta-PPT) | ↑(15.57) | ↓(0.07) | ↓(0.21) | ↓(0.09) | ||
| Total amount | 89/588, 15.1% | 32 | 36 | 70 | 29 | 20 | 83 | |
| Up-regulation | 20(62.5) | 35(97.2) | 5(7.1) | 18(62.1) | 13(65.0) | 15(18.1) | ||
| Down-regulation | 12(37.5) | 1(2.8) | 65(92.9) | 11(37.9) | 7(35.0) | 68(81.9) | ||
- Citation: Li Y, Wan DF, Su JJ, Cao J, Ou C, Qiu XK, Ban KC, Yang C, Qin LL, Luo D, Yue HF, Zhang LS, Gu JR. Differential expression of genes during aflatoxin B1-induced hepatocarcinogenesis in tree shrews. World J Gastroenterol 2004; 10(4): 497-504
- URL: https://www.wjgnet.com/1007-9327/full/v10/i4/497.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i4.497