Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: A pilot phase II clinical trial

Figure 1 A 51 yr-old male patient with neck metastasis of soft palate squamous carcinoma. About 3 mo before enrollment, he had been treated with radiotherapy and Docetaxel plus DDP, but the metastatic tumor did not show any reaction to the treatment. Before the enrollment the tumor was about 2.2 × 1.5 cm² (A, arrow), then the tumor was injected with H101 5 × 10¹¹VP per day for 5 consecutive days with systemic administration of 5-Fu and DDP, after one cycle treatment the tumor regressed (B, arrow).