The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines

Table 1 p53 status, transduction efficacy and IC₅₀ value of 5-FU in pancreatic cancer cell lines; mean ± SD

	Cell line	p53 status	β-gal1%	5-FU-IC50 value1μg/mL
Human
	Capan-1	159 GCC→GTC	92 (4.5)	8.25 (0.45)
	Capan-2	wild type	95 (7.2)	5.75 (0.55)
	FAMPAC	175 CGC→CAT	82 (7.8)	8.00 (0.45)
	PANCL	273 CGT→CAT	82 (7.8)	9.50 (0.75)
Murine rat
	AS	wild type	73 (5.3)	6.55 (0.45)
	DSL6A	Null	83 (6.2)	7.75 (0.55)

¹β-gal was the percentage of X-gal positive cells 24 h after AdlacZ infection at a multiplicity of infection of 50. ²IC₅₀ val-ues were defined for each cell line as the 5-FU concentration leading to 50% growth inhibtion. Results are expressed as mean ± SD from three independent experiments.