Copyright
©The Author(s) 2004.
World J Gastroenterol. Dec 1, 2004; 10(23): 3433-3440
Published online Dec 1, 2004. doi: 10.3748/wjg.v10.i23.3433
Published online Dec 1, 2004. doi: 10.3748/wjg.v10.i23.3433
Resistance mechanism | Genes and ref. | Function |
Plasma membrane | ABCG2 | Belongs to the abc transporter family, appears to play a major role in the multidrug resistance |
transporters/pump | phenotype of MCF-7 breast cancer cell line. When over-expressed, the transfected cells become | |
decrease or increase to | resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular | |
concentration | accumulation reduce intracellular drug of daunorubicin, and manifest an | |
ATP-dependent increase in the efflux of rhodamine | ||
CFTR | Belongs to the abc transporter family. MRP subfamily, involved in the transport of chloride ions | |
RALBP1 | Activates specifically hydrolysis of GTP bound to RAC1 and CDC42. Mediates ATP-dependent | |
transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin(DOX) and is the major | ||
ATP-dependent transporter of glutathioneconjugates of electrophiles (GS-E) and DOX in | ||
erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may | ||
contribute to the multidrug resistance phenomenon | ||
Transcription factor | ATF2 | Belongs to the bZIP family, ATF subfamily, binding the cAMP response element (CRE) |
and/or tumor suppressor | (consensus sequence: 5’GTGACGT(A/C)(A/G)-3') as a transcription activator | |
TP53 | Acts as a tumor suppressor in many tumor types, involved in cell cycle regulation | |
as a transcription activator that acts to negatively regulate cell division by controlling | ||
a set of genes required for this process | ||
The enzymes involved in | CAT | Belonging to the catalase family ,serves to protect cells from the toxic effects of |
drug activation or inactivation | hydrogen peroxide | |
metabolism abnormality | GSTP1 | Belongs to the GST superfamily. Pi family; Conjugation of reduced glutathione to |
a wide number of exogenous and endogenous hydrophobic electrophiles | ||
TOP2B | Control of topological states of DNA by ATP-dependent breakage, passage and | |
rejoining of double-stranded DNA | ||
DCK | Required for the phosphorylation of several deoxyribonucleosides and certain | |
nucleoside analogs widely employed as antiviral and chemotherapeutic agents | ||
Cell signaling alteration and | RAF1 | Belongs to the Ser/Thr family of protein kinases. RAF subfamily. Involved in |
cell cycle checkpoints alteration | the transduction of mitogenic signals from the cell membrane to the nucleus as a | |
part of the Ras-dependent signaling pathway from receptors to the nucleus | ||
SKP2 | Involved in regulation of G1/S transition as substrate recognition component of the | |
SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase complex which mediates the | ||
ubiquitination and subsequent proteasomal degradation of target proteins involved in | ||
cell cycle progression, signal transduction and transcription | ||
Unclear mechanisms | B2M | Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I |
molecules, Containing 1 immunoglobulin-like domain | ||
OCLN | May play a role in the formation and regulation of the tight junction (TJ) | |
paracellular permeability barrier | ||
SPF45 | Involved in nuclear mRNA splicing, via spliceosome |
- Citation: Ding S, Gong BD, Yu J, Gu J, Zhang HY, Shang ZB, Fei Q, Wang P, Zhu JD. Methylation profile of the promoter CpG islands of 14 “drug-resistance” genes in hepatocellular carcinoma. World J Gastroenterol 2004; 10(23): 3433-3440
- URL: https://www.wjgnet.com/1007-9327/full/v10/i23/3433.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i23.3433