Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene

Figure 4 Analysis of pathological changes in the liver of transgenic mice by HE staining. Magnification × 100. A: Mild swollen hepatocytes around the central veins (CV) in the centrilobular region. B: “Ballooning degeneration” around the central veins or between the two central veins in the liver. C: Predominantly lymphocytic cell infiltrates in portal tract area and hepatic lobules. D: Focal necrosis and predominantly lymphocytic cell infiltrates in hepatic lobule. E: Liver of normal mice.