Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam

Table 3 Effects of oral and nasal administration of CII on synoviocytes proliferation in AA rats with or without intragastrical administration of meloxicam (n = 12, mean ± SD)

Groups	Dose (µg/kg)	Synoviocytes proliferation (A490)
Nomal	-	0.27 ± 0.024
AA model	-	0.32 ± 0.045d
AA model + meloxicam	-	0.31 ± 0.025d
AA model + oral CII	20	0.27 ± 0.041b
AA model + nasal CII	20	0.24 ± 0.048b
AA model l + meloxicam + oral CII	20	0.29 ± 0.047a
AA model + meloxicam + nasal CII	20	0.25 ± 0.041bc

^aP < 0.05 vs AA model;

^bP < 0.01 vs AA model;

^dP < 0.01 vs normal control;

^cP < 0.05 vs AA model + meloxicam + oral CII.