siRNA-mediated inhibition of HBV replication and expression

Figure 1 Design of siRNAs specific for HBV genome. A: Down-ward arrows show the target sites within the RNA transcripts. The HBV ORFs are shown below aligned with HBV mRNA. B: Schematic presentation of U6 promoter constructs. The in-verted 19 nt sequences are separated by a 9 nt loop, transcrip-tion ends with 5Ts. The resulting shRNA (short hairpin RNA) are predicted to fold back to form a hairpin RNA.