Yeast expression and DNA immunization of hepatitis B virus S gene with second-loop deletion of &alpha; determinant region

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Oct 15, 2004 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Oct 15, 2004; 10(20): 2989-2993
Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.2989

Table 2 Antigenicity of HBsAg with second-loop deletion of α determinant

Groups	HBsAg titer by IMx S/CO value	Anti-HBs responses in DNA immunization
Groups	HBsAg titer by IMx S/CO value	Positive rate	mIU/L (GMT ± SE)
Empty control	-	0/5	-
pcDNA3	-	0/5	-
pHB	1 589 ± 234.5^b	6/10	27.60 ± 17.3^c
pHB-SD	106 ± 26.8	2/10	4.56 ± 3.52

S/CO: the ratio of sample against cut off value. GMT: geomet-ric mean titer.

^bP < 0.01, t = 5.02 vs groups of pHB-SD;

^cP = 0.02, t = 2.7 vs groups of pHB-SD.

Citation: Hu H, Peng XM, Huang YS, Gu L, Xie QF, Gao ZL. Yeast expression and DNA immunization of hepatitis B virus S gene with second-loop deletion of α determinant region. World J Gastroenterol 2004; 10(20): 2989-2993
URL: https://www.wjgnet.com/1007-9327/full/v10/i20/2989.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i20.2989