Construction of exogenous multiple epitopes of helper T lymphocytes and DNA immunization of its chimeric plasmid with HBV pre-S2/S gene

doi:10.3748/wjg.v10.i20.2979

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Oct 15, 2004 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Oct 15, 2004; 10(20): 2979-2983
Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.2979

Table 2 Effect of MTE5 on anti-HBs response of HBV pre-S2/S gene

Group	Anti-HBs		Enhancement
Group	Positive ratio	MIU/L (GMT ± SE)	Enhancement
Empty control	0/5	-	-
PcDNA3	0/5	-	-
PcHB	6/10	27.60 ± 17.3	-
PcHB/pcMTE5	8/10	136.70 ± 69.1^b	4.95
PcHB-MTEB	7/10	57.540 ± 7.68	2.09
PcHB-MTEX	0/10	-	-
PcHB-MTEH	1/10	1.50	-
PcHB-MTEA	0/10	-	-

GMT: Geometric mean titer; Enhancement: GMT ratio of given group to pcHB, immune enhancement was considered when the ratio was larger than 1. “-” means ant-HBs negative or the enhancement could not be detected.

^bP < 0.01, t = -6.56 vs pcHB group.

Citation: Gao WJ, Peng XM, Xie DY, Xie QF, Gao ZL, Yao JL. Construction of exogenous multiple epitopes of helper T lymphocytes and DNA immunization of its chimeric plasmid with HBV pre-S2/S gene. World J Gastroenterol 2004; 10(20): 2979-2983
URL: https://www.wjgnet.com/1007-9327/full/v10/i20/2979.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i20.2979