A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium

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Oct 15, 2004 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Oct 15, 2004; 10(20): 2958-2962
Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.2958

Table 2 Incidence of dysplasia/cancer and pathology score of UC (mean ± SD)

Group number	Mice	Number of dysplasiae/cancers			Pathology score of UC
Group number	Mice	Proximal	Middle	Distal	Proximal	Middle	Distal
A	11	0.55 ± 0.82	0.73 ± 0.79	2.36 ± 1.12^a	1.82 ± 0.40	1.72 ± 0.46	1.82 ± 0.40^c
B	11	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	2.00 ± 0.63	1.82 ± 0.40	2.09 ± 0.54^c
C	10	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
D	10	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0

^aP < 0.05, significantly different from proximal and middle portion of group A;

^cP < 0.05 significantly different from group D.

Citation: Wang JG, Wang DF, Lv BJ, Si JM. A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium. World J Gastroenterol 2004; 10(20): 2958-2962
URL: https://www.wjgnet.com/1007-9327/full/v10/i20/2958.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i20.2958