ATM and ATR: Sensing DNA damage

doi:10.3748/wjg.v10.i2.155

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Jan 15, 2004 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 15, 2004; 10(2): 155-160
Published online Jan 15, 2004. doi: 10.3748/wjg.v10.i2.155

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Figure 2 Regulation of p53 protein by ATM and ATR. ATM and ATR can influence the activity of p53 directly through phos-phorylation or indirectly through the action of other kinases. Furthermore, ATM can regulate p53 through phosphorylation of Mdm2 molecule, the negative regulator of p53, which can be up-regulated by p53.

Citation: Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN. ATM and ATR: Sensing DNA damage. World J Gastroenterol 2004; 10(2): 155-160
URL: https://www.wjgnet.com/1007-9327/full/v10/i2/155.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i2.155