Copyright
©The Author(s) 2004.
World J Gastroenterol. Jan 15, 2004; 10(2): 209-213
Published online Jan 15, 2004. doi: 10.3748/wjg.v10.i2.209
Published online Jan 15, 2004. doi: 10.3748/wjg.v10.i2.209
Table 1 Characterization of variants in PCR-SSCP and sequence detection
| Family | Abnormal mobility | DNA change | Mutation | Group |
| C4-1 | hMLH1 exon18 | T insert in 2 081 | Frameshift | Typical HNPCC |
| hMSH2 exon15 | C insert in 2 469 | Frameshift | ||
| G insert in 2 471 | Frameshift | |||
| C13-1 | hMSH2 exon11 | T insert in 1 760 | Frameshift | |
| A→C missense in 1 688 | Tyr563Ser | Typical HNPCC | ||
| C11-1 | hMSH2 exon13 | T to A missense in 2 091 | Cys697 | |
| Terminator Condon | Typical HNPCC | |||
| C1-1 | hMLH1 exon11 | A insert in 934 | Frameshift | Atypical HNPCC |
| C8-2 | hMLH1 exon12 | C to G missense in 1 198 | Leu400Val | |
| C to G missense in 1 261 | Val421Leu | |||
| C insert in 1 364 and 1 372 | Frameshift | Atypical HNPCC | ||
| C10-1 | hMLH1 intron10 | — | Polymorphism | Typical HNPCC |
- Citation: Cui L, Jin HY, Cheng HY, Yan YD, Meng RG, Yu DH. Genetic detection of Chinese hereditary nonpolyposis colorectal cancer. World J Gastroenterol 2004; 10(2): 209-213
- URL: https://www.wjgnet.com/1007-9327/full/v10/i2/209.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i2.209