Effects of narcotic analgesic drugs on human Oddi’s sphincter motility

Table 1 Manometric data before and after administration of morphine in 40 patients (mean ± SD)

	Before morphine	10 min after morphine	20 min after morphine
	administration (n = 40)	administration (n = 40)	administration (n = 10)
Oddi’s sphincter basal pressure (mmHg)	8.90 ± 9.11	22.23 ± 16.04b	20.51 ± 13.46b
Amplitude of phasic contractions (mmHg)	50.85 ± 36.66	104.97 ± 49.15d	89.04 ± 62.37d
Frequency of phasic contractions (n/min)	7.22 ± 2.89	9.29 ± 1.93f	8.85 ± 2.42f
Common bile duct pressure (mmHg)	4.97 ± 3.87	8.62 ± 7.43h	7.32 ± 5.95h

^bP,

^dP,

^fP,

^hP < 0.01 vs themselves, n represents the number of patients involved in the research.