Tegaserod inhibits noxious rectal distention induced responses and limbic system c-Fos expression in rats with visceral hypersensitivity

Table 3 Number of c-Fos positive neurons in limbic struc-tures in group H (mean ± SD, n = 8)

	ACC Hippocampus HypoTH Amygdala Thalamus Overall
H-saline	72 ± 10	54 ± 13	51 ± 17	44 ± 16	62 ± 19	283 ± 41
H-vehicle	72 ± 10	54 ± 13	49 ± 15	43 ± 15	62 ± 19	281 ± 37
H-Teg0.1	53 ± 14b	48 ± 10	47 ± 13	42 ± 11	50 ± 13	239 ± 31a
H-Teg0.3	40 ± 11b	45 ± 7	41 ± 11a	37 ± 11	45 ± 11a	208 ± 25b
H-Teg1.0	31 ± 8b	36 ± 9b	31 ± 10b	30 ± 8b	34 ± 10b	162 ± 16b
F value	60.583	11.605	8.199	5.362	14.574	61.989
P value	0.000	0.000	0.000	0.000	0.000	0.000

^aP < 0.05,

^bP < 0.01 vs H-saline.