Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication

Figure 3 Effects of lidamycin on cell cycle. BEL-7402 cells were treated with 0.5 nmol/L lidamycin for 2 h, then washed and fed with fresh medium. After 72 h of incubation, the cells were stained with propidium iodide and sorted by flow cytometry. A, B: Untreated BEL-7402 cells; C, D: 0.5 nmol/L lidamycin treated BEL-7402 cells. The changes indicated in dot density maps were in accordance with those displayed in histograms.