Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication

Figure 2 Induction by lidamycin of atypical chromatin condensation and multinucleation in BEL-7402 cells, determined by staining with the fluorescent dye Hoechst 33342 at 72 h after exposure to 0. 1 nmol/L and 0.5 nmol/L lidamycin for 2 h. A: Untreated BEL-7402 cells; B: 0.1 nmol/L lidamycin treated BEL-7402 cells; C: 0.5 nmol/L lidamycin treated BEL-7402 cells.