Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide

Table 6 Effects of melatonin on MDA, TNF-α and IL-1 released from co-cultured normal rat hepatocytes and Kupffer cells activated by BCG (n = 5, mean ± SE)

Group	Concentration of melatonin (mol/L)	ALT (U/L)	MDA (nmol/L)	TNF-α (ng/L)	IL-1 (A570 nm)
KC + HC	---	37.1 ± 3.7	0.506 ± 0.029	4.50 ± 0.78	0.16 ± 0.03
KC + HC + LPS		81.4 ± 6.4d	0.849 ± 0.062d	11.36 ± 1.6d	0.25 ± 0.03d
KC + HC + LPS + Melatonin	10-9	82.4 ± 4.3	0.809 ± 0.015	10.13 ± 0.23	0.26 ± 0.02
	10-8	79.6 ± 5.4	0.789 ± 0.036	9.49 ± 0.52	0.24 ± 0.02
	10-7	74.9 ± 4.2	0.706 ± 0.014b	8.54 ± 0.81b	0.22 ± 0.01
	10-6	72.9 ± 6.6	0.676 ± 0.043b	8.21 ± 0.37b	0.19 ± 0.01a
	10-5	83.8 ± 3.3	0.69 ± 0.04b	8.39 ± 1.22b	0.20 ± 0.01b

KC: Kupffer cell;

^aP < 0.05,

^bP < 0.01 vs model group;

^dP < 0.01 vs normal control group.