Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide

Table 5 Effect of melatonin on TNF-α, IL-1 and NO released from cultured normal Kupffer cells of rats (n = 10, mean ± SE)

Group	Concentration of melatonin (mol/L)	TNF-α (ng/L)	IL-1 (A570 nm)	NO (μmol/L)
KC	---	4.25 ± 0.79	0.137 ± 0.03	13.65 ± 0.21
KC + LPS		11.21 ± 1.63d	0.233 ± 0.03d	18.85 ± 0.88d
KC + LPS + melatonin	10-9	9.96 ± 0.24	0.238 ± 0.02	19.08 ± 0.40
	10-8	9.31 ± 0.53a	0.223 ± 0.02	19.13 ± 0.46
	10-7	8.35 ± 0.82b	0.201 ± 0.01	18.90 ± 0.77
	10-6	8.01 ± 0.38b	0.177 ± 0.01b	18.65 ± 0.61
	10-5	9.74 ± 0.39	0.216 ± 0.02	18.70 ± 0.57

KC: Kupffer cells;

^aP < 0.05,

^bP < 0.01 vs model group;

^dP < 0.01 vs normal control group.