Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide

Table 4 Effects of melatonin on TNF-α, IL-1 and NO levels of liver homogenates in immunological injury mice (n = 10, mean ± SE)

Group	Dose (mg/kg bm)	TNF-α (ng/L)	IL-1 (A570 nm)	NO (μmol/L)
Normal	---	3.1 ± 8.3	0.15 ± 0.03	9.5 ± 2.7
Model	---	26.6 ± 2.3d	0.41 ± 0.03d	45.0 ± 9.8d
Melatonin	0.25	13.9 ± 2.9b	0.38 ± 0.13	25.6 ± 9.5b
	1.0	12.4 ± 2.9b	0.22 ± 0.05b	17 ± 11b
	4.0	17.9 ± 4.8b	0.35 ± 0.04b	24 ± 10b

^aP < 0.05,

^bP < 0.01vs model group;

^dP < 0.01 vs normal control group.