Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide

Table 3 Effects of melatonin on serum TNF-α, IL-1 and NO levels in immunological liver injury mice (n = 10, mean ± SE)

Group	Dose (mg/kg bm)	TNF-α (ng/L)	IL-1 (A570 nm)	NO (μmol/L)
Normal	---	1.61 ± 0.76	0.107 ± 0.001	9.82 ± 1.92
Model	---	4.80 ± 1.61d	0.242 ± 0.03d	73 ± 19d
Melatonin	0.25	3.42 ± 1.08a	0.183 ± 0.07a	55 ± 18a
	1.0	3.26 ± 0.73a	0.131 ± 0.04b	28 ± 14b
	4.0	2.64 ± 1.19b	0.158 ± 0.04b	56 ± 19a

^aP < 0.05,

^bP < 0.01 vs model group;

^dP < 0.01 vs normal control group.